مؤسسة الشرق الأوسط للنشر العلمي
عادةً ما يتم الرد في غضون خمس دقائق
Over the past decade: the problem has evolved into one of the major health issues worldwide. The problem is even more dire in the context of children, as a result of their vulnerability due to uncontrollable infections. The most important pathogens that have shown a rise in resistance to commonly used antibiotics include MRSA, S. aureus, and E. coli. Understanding these resistance profiles is very important in the development of better treatment methods for the best outcomes in patient care. This study was thus designed to investigate the antibiotic resistance patterns of MRSA, S. aureus, and E. coli in pediatric admissions at Al. Om Elhanon Hospital in Libya as part of the effort to understand local resistance patterns with a view toward appropriate therapeutic approaches. Materials and Methods: The study to be undertaken is classified as cross-sectional and was conducted at the Al Om Elhanon Hospital, which is a major health facility in Libya that deals particularly with children. A cumulative of [insert number] bacterial isolates were derived from pediatric patients who were diagnosed with infections caused by MRSA, S. aureus, and E. coli. Its antibiotic susceptibility was determined by the disk diffusion technique following recommendations provided by CLSI. This work estimated the resistance pattern of several antibiotics like penicillins, cephalosporins, and carbapenems in order to describe the resistance rate and the degree of resistance of the strains isolated. Results: The strains of MRSA, S. aureus, and E. coli showed considerable resistance against all those antibiotics. MRSA showed a very high level of resistance, especially against methicillin and the other beta-lactam antibiotics. S. aureus strains showed all kinds of variable resistance against each of the antibiotics used in this study. E. coli also demonstrated a considerable level of resistance to fluoroquinolones and extended-spectrum cephalosporins. The resistance profiling previously mentioned speaks to the great need that already exists for the use of targeted antibiotic treatment. Moreover, this suggests a possibly concerning increase in the multi-drug-resistant strains within the pediatric cohort at this hospital. These findings of this study indicate the growing need to improve antimicrobial stewardship and apply regular surveillance for antibiotic resistance in this pediatric population. From this perspective, current resistance patterns are very likely to require a revision of the guidelines for empirical treatment, with consideration of local trends in resistance to ensure effectiveness against prevailing challenges.