مؤسسة الشرق الأوسط للنشر العلمي
عادةً ما يتم الرد في غضون خمس دقائق
Historical reliance on Tinnevelly senna (Senna alexandrina Mill.) within traditional pharmacopoeias underscores its potential as a reservoir for novel antimicrobial scaffolds. This investigation dissects the chemical architecture and bactericidal efficacy of methanolic leaf and pod extracts through a multi-analytical lens. High-Performance Liquid Chromatography (HPLC) revealed that sennosides A and B constitute the primary bioactive markers, with leaf matrices exhibiting superior concentrations—specifically 25.3 mg/g and 27.8 mg/g, respectively. Biological assays demonstrated significant inhibitory zones against Escherichia coli and Pseudomonas aeruginosa. Computational modeling reinforced these findings; sennoside B displayed a notable binding affinity of -8.7 kcal/mol against the E. coli DNA gyrase B subunit, suggesting a targeted mechanical disruption of bacterial replication. These results advocate for the strategic integration of senna-derived glycones into the development of sustainable antibacterial therapies.