مؤسسة الشرق الأوسط للنشر العلمي
عادةً ما يتم الرد في غضون خمس دقائق
Adriamycin, an anthracycline antibiotic, is used for certain cancer treatments but is known to be a teratogen for pregnant women, leading to Caudal regression, a rare congenital malformation affecting lower limbs and vertebrae, causing respiratory, renal, reproductive, and anal issues. In this study, we incubated the eggs for about 2days (48h). the embryos were divided into 3 groups, each group containing 10 embryos. The first group (G1) was the control, the second group (G2) was treated with distilled water, and the third group (G3), was injected with a dose of Adriamycin 0.1 mg/kg. Then the egg groups were returned to the incubator again to complete growth. embryos were collected at two different stages HH24 and HH31. The study found that embryos treated with Adriamycin exhibited caudal regression defects exceeding 90%, with secondary malformations appearing in the head and trunk regions. Also this study found, adriamycin could cause caudal regression in chick embryos by inhibiting the shh signaling pathway, there is a correlation between shh signaling absence and caudal regression. Comparatively, both Adriamycin-treated and cyclopamine-treated embryos exhibited noticeable caudal regression, highlighting the impact of inhibiting the shh signaling pathway.