مؤسسة الشرق الأوسط للنشر العلمي
عادةً ما يتم الرد في غضون خمس دقائق
Abstract
Introduction: Lung cancer is the most lethal cancer worldwide. Adenocarcinoma is the most common form of lung cancer. Adenocarcinoma is also the most frequently diagnosed subtype in women, as well as in non-smokers. Materials and methods : In this experimental study, we assessed valproic acid versus sodium dichloroacetate effect upon lung adenocarcinoma cell line A549 in vitro via microscopic examination ,flow cytometry and gene expressions by using real-time PCR technique. Results : Each substance has an apoptotic effect on A549 cells in vitro. The apoptotic effect of valproic acid on A549 cells in vitro is mediated via up-regulation of NOTCH-1 gene while that apoptotic effect of sodium dichloroacetate is mediated via down-regulation of PDKII gene. Up-regulation of STAT3 gene is associated with each substance. Conclusion: The apoptotic effect of valproic acid is more potent than that apoptotic effect of sodium dichloroactate on A549 cell line in vitro.